D4-GDI Signaling Pathway
| PAG Title | D4-GDI Signaling Pathway |
| PAG ID | WIG000301 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa Size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. |
| Species | Homo sapiens |
| nCoCo Score | 2,192 |
| Base PAG ID | WIG000301 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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